Articles Tagged With:
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Surge of Scientific Fraud Is a Persistent, Rapidly Growing Ethical Problem
The rise of “paper mills” producing fraudulent research is undermining scientific integrity. Systemic pressures, institutional complicity, and weak detection systems accelerate the problem, threatening public trust in science and posing risks to health research.
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Organ Donation Practices Are Being Ethically Scrutinized: Communication Is a Key Concern
Ethical controversies in organ donation include missteps during procurement, poorly timed family communication, and debate over normothermic regional perfusion. Transparent dialogue, ethical safeguards, and better clinician training help to uphold patient and family values.
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What Are Hyperacute T-Waves and What Do They Mean?
A retrospective study of emergency department patients suspected of having an acute coronary syndrome has shown that a computer system for determining a new quantitative high-amplitude electrocardiogram (ECG) T-wave score has a high specificity and reasonable sensitivity for identifying patients with acute coronary occlusion that performs as well as ECG ST-elevation myocardial infarction criteria.
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Statins for Abdominal Aortic Aneurysms
An analysis of two large, abdominal aortic aneurysm (AAA) screening populations from Denmark has shown that high-dose statin therapy reduces the rate of AAA growth, the need for repair, and adverse outcomes, such as rupture and death.
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Withdrawing Heart Failure Medications After Restoring Sinus Rhythm in AF Cardiomyopathy Patients
A small trial of withdrawing guideline-directed medical therapy (GDMT) for reduced ejection fraction (EF) heart failure in patients with atrial fibrillation in whom EF recovered after restoration of normal sinus rhythm has shown that withdrawal of GDMT was not associated with a decline in EF over 12 months in most patients.
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Beta-Blocker Interruption Post-MI
An analysis of the secondary outcomes in the French multicentered study of beta-blocker withdrawal in patients with uncomplicated myocardial infarction after one year led to increases in heart rate and blood pressure with potentially deleterious outcomes, especially in patients with a history of hypertension.
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Routine CCTA Imaging of Left Main PCI Patients Falls Short in Randomized Trial
In this randomized trial of patients undergoing left main percutaneous coronary intervention, routine surveillance coronary computed tomography angiography six months after intervention did not reduce the composite endpoint of all-cause death, myocardial infarction (MI), unstable angina, or stent thrombosis at 18 months, but was associated with fewer spontaneous MIs and more imaging-triggered revascularization procedures.
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Diabetic Emergencies
Although diabetes affects various organ systems and complicates other disease processes, pure diabetic emergencies include diabetic ketoacidosis, hyperosmolar hyperglycemic syndrome, euglycemic diabetic ketoacidosis, and severe hypoglycemia. These emergencies often are precipitated in a patient with known diabetes but frequently can be the initial presentation in someone with undiagnosed diabetes. It is essential for ED providers to understand the pathophysiology, clinical features, workup, and management of these conditions, since they can be fatal, as they often were before the availability of insulin.
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Treated as Aberrant SVT
I was given this electrocardiogram without knowing details of the history beyond that the patient was an older man who was hemodynamically stable. He was being treated on the assumption that the rhythm was a supraventricular tachycardia with QRS widening because of aberrant conduction. Do you agree with this assumption? How certain are you of your answer
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Sunvozertinib (Zegfrovy) Tablets
The U.S. Food and Drug Administration (FDA) has granted an accelerated approval to sunvozertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of non-small cell lung cancer with epidermal growth factor receptor (EGFR) exon 20 insertion mutations (EGFR exon20ins). The FDA also approved a companion diagnostic device, Oncomine Dx Express Test to help detect exon20ins mutations.